Top 10 Incurable Diseases in The World You Should Know

In this rapidly changing environment of the Earth, we are struck by a barrage of different negative factors. These factors include global warming and much more which is a growing concern for the birth of many severe diseases. However, severe is just a word to classify the deadliest diseases. The most severe amongst the terminal diseases are those which have no cure yet. If one encounters such a disease, he/she has no permanent escape from the trouble and mostly relies on temporary treatment. Such incurable diseases have bothered mankind through many generations. Even though millions of dollars are spent annually for the research of the cure for such diseases, mankind still hasn’t been able to prove itself in some cases. Here’s some more details about these deadliest and incurable fatal diseases.


Incurable Diseases
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Amongst other life threatening diseases, “Rabies” a viral disease sprouting more than 150 countries. Once the clinical symptoms start to appear, the results caused are mostly fatal. First acute inflammation of the brain begins following violent movements, headaches, uncontrollable emotions, paralysis, insomnia, hallucinations, delirium, coma, paranoia, agitation, loss of consciousness, state of confusion etc. The beginning of the symptoms is dependent on the speed at which this contagious infection reaches Central nervous system (CNS) via peripheral nerves. Cats, dogs, foxes, monkeys, wolves and dogs contribute in the transmission of rabies virus in humans. The preventive method present is vaccinating infect prone animals. Though it can be prevented, but once one gets infected, there is no cure.

9-Lupus Erythematous

Incurable Diseases

All the auto immune diseases are categorized under one heading ‘lupus erythematous’. As the name suggests it is linked with the body’s immune system which instead of attacking foreign particles like bacteria, it attacks body’s own cells damaging the tissue. Chest pain, oral ulcer, fatigue, joint pain, fever with no other reason, hair loss, skin rash, swollen lymph nodes are common signs and symptoms of lupus. It mainly develops in ages 15-44. This disorder can initiate even in strong and smooth working immune systems due to environmental changes such as cosmic rays, trauma and emotional stress. Blood tests, chest X-rays, urinalysis helps the doctor to diagnose this. Anti-inflammatory medicines, steroid cream are used to get rid of its symptoms but no lifelong cure is available.

8-Fatal Familial Insomnia

Incurable Diseases

(FFI) is extremely rare inherited disease. It has no cure and keeps on worsening causing hallucinations, delirium, confused states, high blood pressure, hyperventilation etc. The average life of the individual after the commencement of this disease is 18 months. This usually occurs due to gene mutation. Use of gene therapy, sleeping pills proved to be a complete failure in fighting fatal familial insomnia. Only doxycycline has been able to slow the developmental pace of fatal familial insomnia.

See Also: Top 10 Worst Diseases in The World

7-Creutzfeldt Jakob Disease

Incurable Diseases
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It is commonly known as mad cow disease. It is basically a neurological disease. In this disease, brain tissues degenerate very quickly causing holes in brain. When an affected person is examined, the holes in brain tissue resemble to the sponge holes and brain looks like a sponge. Loss of memory, change in personality, depression, anxiety, hallucinations and psychosis are common signs and symptoms. The main cause of this can be gene mutation. Agents required for its effective distribution are blood, transplanted cornea, injections contaminated with pituitary growth, hormones etc. In short it spreads via brain linked tissues and fluids. A person with Cruetzfeldt Jacob disease (CJD) cannot be cured and his ultimate fate is death.


Incurable Diseases

It is a metabolic disease. A diabetic (a patient of diabetes) has high level of blood sugar. Symptoms of diabetes include frequent urination usually at night time. Furthermore, increased thirst and hunger, sudden weight loss, feeling fatigued and blurred vision are additional symptoms. There are two types of diabetes. In Type 1 body immune system destroys beta cells of islets of Langerhans in pancreas which produce insulin. This is commonly known as insulin dependent diabetes. Once detected, one is bound to take insulin injections on daily basis. The Type 2 is linked with the lack of production of insulin which is more commonly known as insulin resistance type. Several medications and insulin injection are present but no permanent cure is discovered yet.


Incurable Diseases

Progeria includes in the list of incurable genetic diseases. Progeria syndrome is basically a genetic disorder. Its symptoms usually develop in the first few months after child is born. As time passes, aging is visible, alopecia (hair loss) , small face with pinched nose having a beak like tip, loss of weight, high pitched voice all are initial symptoms. Later on, several health issues become visible like hip dislocation, fragile bones, stiff joints, insulin resistance develops.

Moreover, skin becomes hardened, tightened and wrinkled, atherosclerosis, kidney failure and loss of eyesight occurs. Head enlarges and veins become visible. Death of children with Progeria usually occurs because of heart attack or stroke. Physical examination, vision and hearing test, pulse rate and blood pressure checkup can help in its diagnostics. A positive test for LMNA mutation assures presence of this disease. Its treatment comprises of occupational and physical therapies and low dose aspirin but no treatment is effective in curing it permanently.


Incurable Diseases
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Polio or Poliomyelitis is a contagious disease caused by Poliovirus (PV). In the case of encountering this virus, muscle weakness occur leading to inability to move; in short paralysis. Weakness usually affects legs and very rarely head, neck muscles and diaphragm. Minor symptoms include headache, sore throat, fever, neck stiffness, pain in arms and legs. Usually its transmission occurs in summers and autumn via fecal or orally. Infection is present in feces and saliva. A specimen of stool or liquid from pharynx is used to identify the presence of virus.

There are two types of vaccines used to fight polio and both of them promote immunity against polio hence stopping person to person transmission. There is no cure for polio but treatment is available in form of orthopedic surgery, antibiotics, nutritious and healthy diet, physical, occupational, hydro and electro therapies. Polio has been reduced by over 99% from around the world. Only two countries (Pakistan and Afghanistan) are still effected by polio in the world.


Incurable Diseases
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Cancer or malignancy is the abnormal growth of body cells which have the ability to spread in rest of the body parts. There are over 100 types of cancers like skin, lung, breast and many more. All of them have different signs and symptoms but common to all is formation of lumps, abnormal bleeding and weight loss. Routine self-examination can help in the detection of cancer but is applicable on only few kinds for example rectum, prostrate, skin, breasts, mouth and testicle cancers.

If it became terminal cancer, Life can’t be saved. But if it get detected early, in such case, a patient’s entire medical history is examined carefully. Medical imaging like X-Rays, CT and MRI help doctors to exactly understand the position of cancer. Once its existence is confirmed treatment is started. The treatment of cancer includes radiation therapy, hormone therapy, immunotherapy, chemotherapy and surgery. Though temporary treatment is present but there is NO PERMANENT CURE.


Incurable Diseases

Human Immune Deficiency Virus and Acquired Immune Deficiency Syndrome are linked with human immune system. Immune system is one which resists any negative change that tries to bother our body internally. Such kind of infection usually transfers through blood transfusion, during child birth from mother to child, unsterilized injections’ use on multiple individuals for the dosage of drugs. It is also caused during sexual intercourse. HIV symptoms

One cannot infected with HIV/AIDS if exposed to feces, urine, nasal secretion, vomit, sputum, saliva and sweat tears. Through laboratory tests, it can be diagnosed. Its treatment consists of antiretroviral therapy but currently no cure is present that can permanently kill it.


incurable diseases

Among all incurable diseases “Ebola” is the most fatal one. Scientist believes that Ebola virus originate from Insect eating bats that populated in a hollow tree from a village in Guinea.

The Ebola Virus Disease (EVD) or Ebola Hemorrhagic Fever (EHF) has its main root causes in four different types of dangerous viruses. The signs and symptoms typically begin after two days and three weeks. At first fever, sore throat, muscular pain, headaches are faced by the infected person. It continues with addition of vomiting, diarrhea, rash and reduced function of kidneys and liver. External and internal bleeding also starts. Several bodily fluids act as medium of transfer of this virus from one individual to another. These include breast milk, semen, saliva, urine, mucus, vomits, feces, sweat tears etc. To control the infection from spreading, one should wear gloves, goggles, masks, protective gears and should avoid contact with infected person. Till present day no effective medication is present hence there is no cure for Ebola virus.

The list of incurable diseases is quite long. Some other incurable illnesses are mentioned below.


Commonly known as ‘flu’, this is an infectious viral disease caused by Influenza virus. Having fever, runny nose, sore throat, muscle pain, headache, frequent coughing, feeling fatigued indicates that you have influenza. There are three types of influenza which are named as A, B and C viruses. It can be transmitted via air when an infected person sneezes, coughs or even spits. People with diabetes, asthma, heart diseases and weak immune system are more prone to this virus. Plenty of water and bed rest is the key to fight flu but medicines are also available still it’s incurable.

Common Cold

Common cold is often thought as a normal and routine virus. However, it is a viral infectious disease. This affects nose, upper respiratory tract, throat, sinuses and voice box. 2 days after disclosure to infection, symptoms like cough, sore throat, runny nose, headache, fever and severe sneezing show up. Its recovery time is 7 to 10 days if no artificial ways e.g. antibiotics are used. It’s transmitted via aerosols or fomites (clothes, furniture and utensils). Environmental factors may also contribute in this as long as unprotected exposure to cold weather isn’t avoided. The treatments available for this are analgesics like paracetamol etc. But these are just treatments and no permanent cure is available that can make you immune from common cold forever.

  • Asthama
  • Schizophrenia

In short, let us pray that no one ever becomes exposed to any of such terminal illness. If incurable diseases symptoms appear, it is in the genes of someone, the person must take extreme care and ensure regular check-ups to not only make yourself safe but also keep your family safe! Will power can be used as a fight against such diseases without cures. So, feel healthy and stay healthy!